Which condition is treated with collagenase injections?

• A. Trigger finger
• B. Dupuytren's contracture
• C. Carpal tunnel syndrome
• D. Osteoarthritis

Answer: (B)

Enzymatic dissolution of the palmar fascia cords is used to treat this condition. Collagenase injections target the thick collagen cords that pull the fingers into flexion in Dupuytren’s contracture. The injected enzyme weakens and breaks down these cords, and a subsequent controlled finger extension maneuver helps rupture the cord, allowing the finger to straighten. This approach is less invasive than surgical fasciectomy and can restore extension without surgery in many cases. Post-injection care focuses on range-of-motion exercises and wound care, with possible temporary swelling or skin irritation at the injection site and a small risk of recurrence later. Other conditions—trigger finger typically treated with corticosteroid injections or surgical release; carpal tunnel syndrome with splints or surgical decompression; osteoarthritis with analgesics or intra-articular therapies—do not involve collagenase for cord dissolution.